Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics

Abstract Oxidation is a prominent degradation route of biological molecules that produces wide variety products through complex mechanisms and hence qualifies to be vital pharmaceutical process. This article presents the kinetic spectral study oxidation an antimigraine drug rizatriptan benzoate (RTB) in acid medium with aid mild biocidal oxidant N -chloro- p -toluenesulfonamide, referred as chloramine-T (CAT). The experimental studies reported here, such fractional order dependency on RTB, pseudo-first-order CAT, negative medium, independent rate ionic concentration increasing dielectric constant, have led evaluation stoichiometry, thermodynamic properties, derivation equation. Effective interpretation UV–Vis, IR, 1 H 13 C NMR investigation was performed identify confirm identity discuss involved plausible mechanism. provides extended insight into formed during metabolism RTB.